A 34-year-old Hispanic-American male with end-stage renaldisease received kidney transplant from a cadaver donor, as no onein his family was a good match. His post-operative course wasuneventful, and he was discharged with the antirejection drugsTacrolimus (Prograf), Cyclosporine (Neoral), and Imuran(Azathioprine). He did well for 3 months and had returned to hisjob as a policeman. Six months after his transplant, he began togain weight, had decreased urine output, was very fatigued, andbegan to run temperatures up to 101˚F. He was evaluated by hisnephrologist, who diagnosed acute kidney transplant rejection.
Why is the patient presenting this symptoms from the abovescenario?
What genes is associated with development of the disease?
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