Question: Mutations In The Recombinase Activating Genes (RAG1 And RAG2) Can Lead To Severe Combined Immunodeficiency (SCID). Infants Born With SCID Experience Severe, Recurrent Infections. The Early Infections In These Infants Are Typically Viral Infections, Rarely Bacterial Infections. A) Explain What Would Be Defective In These Newborns. Provide Specific, Cellular ...

Mutations in the recombinase activating genes (RAG1 and RAG2)can lead to Severe Combined Immunodeficiency (SCID). Infants bornwith SCID experience severe, recurrent infections. The earlyinfections in these infants are typically viral infections, rarelybacterial infections.

a) Explain what would be defective in these newborns. Providespecific, cellular and molecular mechanisms.

b) Why are bacterial infections less common in these newborns?Hint: SCID children WILL gradually become more susceptible tobacterial infections as they grow older.

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