Question: Why do you suppose that the concentration of p53 is controlled by its degradation rather than at …

Why do you suppose that the concentration of p53 is controlled
by its degradation rather than at the level of its transcription
like many other proteins? Why do you suppose that the concentration
of p53 is controlled by its degradation rather than at the level of
its transcription like many other proteins?

a. Control of p53 degradation by ubiqitylation can be reversed
after the ubiquitin is added.

b. It is difficult for a cell to activate transcription via
phosphorylation events.

c. Protection from degradation allows for a much faster build up
in response to changes in cellular conditions.

d. Transcription is halted when there is DNA damage.