Question: The strength of GDP binding to the G protein is reduced by
G-protein-linked receptors (GPLRs), re…
The strength of GDP binding to the G protein is reduced by
G-protein-linked receptors (GPLRs), resulting in activation of the
G protein. The reduction in GDP binding strength results in the
rapid exit of GDP which is replaced by GTP, because GTP is present
at much higher concentrations in the cytosol than GDP. If you
created an G-protein α-subunit mutant that caused its affinity for
GDP to be reduced without significantly changing its affinity for
GTP, what would you predict the consequences to be? B) Compare
these predicted effects with those of the cholera toxin.
G-protein-linked receptors (GPLRs), resulting in activation of the
G protein. The reduction in GDP binding strength results in the
rapid exit of GDP which is replaced by GTP, because GTP is present
at much higher concentrations in the cytosol than GDP. If you
created an G-protein α-subunit mutant that caused its affinity for
GDP to be reduced without significantly changing its affinity for
GTP, what would you predict the consequences to be? B) Compare
these predicted effects with those of the cholera toxin.
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