Question: 2. Two nonhomologous chromosomes in a woman’s primary oocyte have the gene loci FGHI • JKLMN and …

2. Two nonhomologous chromosomes in a woman’s primary oocyte
have the gene loci FGHI • JKLMN and PQ • RSTUVW. In that cell there
is a reciprocal translocation in which the LMN and VW segments are
mutually exchanged. Both translocated chromosomes are segregated to
an ovum which is then fertilized by a sperm that has no chromosomes
with rearrangements, leading to a daughter. Later, as that daughter
matures, her oocytes begin meiosis.

a) Draw how the four chromosomes (2 translocated, 2 normally
arranged) will synapse at Meiosis I. Include the gene loci and
centromeres in the drawing. (3 points)

b) There are two common ways in which these chromosomes may
segregate at Anaphase I. For each of those ways, draw the contents
of the gametes that will result, and indicate which of them would
likely lead to inviable offspring. (8 points)