Question: Mutation of a cystein residue C124 to serine (C124S) renders the PTEN protein unable to perform i…

Mutation of a cystein residue
C124 to serine (C124S) renders the PTEN protein unable to perform
its phosphatase activity. wild-type PTEN and the C124S PTEN mutant
were both tagged with His-Ni and purified. They were each
independently incubated in vitro with an equal amount of histones
for detection of PTEN-bound histone H1. The result of the
co-precipitation is presented in the figure below. Is the
phosphatase activity of PTEN necessary for its interaction with
Histone 1? Explain the relevant part of the figure to justify your
answer.