Question: Somatic Cell Hybridization
3 mouse-human hybrid cell lines retained specific human
chromosomes af…



Somatic Cell Hybridization

3 mouse-human hybrid cell lines retained specific human
chromosomes after many generations as shown in this data.

Human Chromosomes
X 3 5 7 9 17 20 21
Cell Line
A + + + + 0 0 0 0
B 0 + 0 + 0 + 0 +
C 0 0 + + 0 0 + +

Assays were performed for the presence of 8 different human
enzymes (E1-E8) in each of the 3 cell lines. These were the
results:

Enzyme Activity
E1 E2 E3 E4 E5 E6 E7 E8
Cell Line
A + 0 + + 0 + 0 0
B + 0 0 + + 0 + +
C + + + 0 0 + 0 +

Identify the human chromosome that carries the gene for each
enzyme.

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