Question: Bee venom contains phospholipase A2, which is responsible for some of the inflammatory effects of…

Bee venom contains phospholipase A2, which is responsible for
some of the inflammatory effects of a bee sting. A schematic
drawing of the actice site is shown below. Notice the aspartate and
histidine residues in the active site, as well as the positions of
the water molecule. Based on what you have learned about protease
mechanisms, propose a chemical mechanism for the phospholipase A2
reaction. In your answer show Ca2+, Gly10, His34 and Asp64 at each
step; the other residues do not need to be included in your answer.
IMPORTANT: Each step in your mechanism should be
enclosed in a box. Answers must be neatly drawn.