Question: Protein tyrosine phosphatases (PTPs) are a diverse family of signaling enzymes that, together wit…
Show transcribed image text Protein tyrosine phosphatases (PTPs) are a diverse family of signaling enzymes that, together with protein tyrosine kinases, modulate the cellular level of tyrosine phosphorylation. Phosphorytation/dephosphorylation of tyrosine is reversible process for cell signaling. Zhang, Acc, Chem, Res., 2003, 36(6), 385-392 Draw the phosphorylated tyrosine residue of a protein. By catalyzing removal of a phosphoryl group from a substrate, phosphatases act as: a. Both "on" or "off" switches for signal transduction. b. On switches for signal transduction. c. Off switches for signal transduction. Use curved arrows for the mechanism of the PTP-1B. Show a mechanism for how the active site of the catalyst is returned to the starting point after the substrate leaves.
Protein tyrosine phosphatases (PTPs) are a diverse family of signaling enzymes that, together with protein tyrosine kinases, modulate the cellular level of tyrosine phosphorylation. Phosphorytation/dephosphorylation of tyrosine is reversible process for cell signaling. Zhang, Acc, Chem, Res., 2003, 36(6), 385-392 Draw the phosphorylated tyrosine residue of a protein. By catalyzing removal of a phosphoryl group from a substrate, phosphatases act as: a. Both "on" or "off" switches for signal transduction. b. On switches for signal transduction. c. Off switches for signal transduction. Use curved arrows for the mechanism of the PTP-1B. Show a mechanism for how the active site of the catalyst is returned to the starting point after the substrate leaves.
