Question: Let’s suppose an X-linked gene in mice exists as two alleles,
which we will call B and b. X inact…



Let’s suppose an X-linked gene in mice exists as two alleles,
which we will call B and b. X inactivation, a process in which one
X chromosome is turned off, occurs in the somatic cells of female
mammals (see Chapter 5). Allele B encodes an mRNA that is 900
nucleotides long, whereas allele b contains a small deletion that
shortens the mRNA to a length of 825 nucleotides. Draw the expected
results of a Northern blot using mRNA isolated from somatic tissue
of the following mice: Lane 1. — mRNA from an Xb Y male mouse
Lane 2. — mRNA from an Xb Xb female mouse Lane 3.—- mRNA from
an XBXb female mouse.

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