Question: In the budding yeast, activation of the GTP-binding protein Cdc42 occurs on binding of an externa…

In the budding yeast, activation of the GTP-binding protein
Cdc42 occurs on binding of an external signal (pheromone) to a
G-protein-coupled receptor. Activation of Cdc42 promotes actin
polymerization. Predict what would happen to actin polymerization,
in comparison with pheromone-treated cells, in the following
cases.

A. You add pheromone to an inhibitor of G-protein-coupled
receptors.

B. You add pheromone to a nonhydrolyzable analog of GTP.