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7. What other findings are consistent with the possibility of war hemolic process? 8. In a newborn demonstrating evidence of a hemolytic anemia, what is the most likely cause? CASE STUDY HZ Jeffrey C., a 6-year-old boy, was seen by a maxillofacial surgeon to be evaluated for surgical repair of severe jaw misalignment. The youngster was deemed an appropriate candidate for surgery at this time with a second surgery planned during his teen years to complete the correction. The child was adopted, and no family history was available. He had no personal history of excessive bleeding or bruising. The pre-surgical CBC results including platelet count were within reference ranges. Pre-surgical hemostasis testing follows Jeffrey Reference Range Prothrombin time 105 90-120 sec APTT 400 320 – 46.0 sec Bleeding time 1.0-90 min 7 QUESTIONS 1. Describe the principle and reagents for the prothrombin time and the APTT test. Jeffrey was taken to surgery but experienced excessive bleeding during surgery and continued coring and bleeding postoperatively. Prothrombin time, APTT, and bleeding times performed postoperatively follow: Jeffrey Reference Range Prothrombin time 10.5 9.0 -12.0 sec АРТТ 480 32.0 – 45.0 sec 8 Bleeding time 1.0-9.0 min 31 Page
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