Question: Botulinus toxin causes paralysis. It binds to presynaptic sites
at the motor end plate (neuromusc…
Botulinus toxin causes paralysis. It binds to presynaptic sites
at the motor end plate (neuromuscular junction) and prevents the
exocytosis release of transmitter from vesicles. Predict the
consequences (increase, decrease, no change) of blocking the
acetylcholine at the neuromuscular junction on the following.
Explain your predictions for each
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1. Presynaptic resting potential |
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2. Presynaptic action potential amplitude |
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3. Presynaptic Ca++ Influx |
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4. Presynaptic transmitter release |
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5. Postsynaptic resting potential |
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6. Postsynaptic end plate potential |
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7. Postsynaptic action potential amplitude |
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8. Postsynaptic action potential frequency |
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9. Muscle contraction strength |
