Question: A chemist working for a drug company synthesizes four molecules that bind to the androgen recepto…
Show transcribed image text A chemist working for a drug company synthesizes four molecules that bind to the androgen receptor. You carry out a quantitative binding assay for each of these compounds using a purified androgen receptor preparation and determine the following K_d values for the compounds: 1 Times 10^-3 M 1 Times 10^-6 M 2.5 Times 10^-7 M 1 Times 10^-10 M Which of the compounds has the greatest affinity for the androgen receptor? The K_D for binding of insulin to its receptor on liver cells is 6 Times 10^-10 M, and the ambient blood concentration of insulin in liver tissue is 3 Times 10^12 M. What percent of insulin receptors on these liver cells will have bound insulin? (show calculation) If the insulin concentration increases 10-fold (to 3 Times 10^-11 M), what percentage of insulin receptors on these liver cells will have bound insulin?(show calculation) What minimum concentration of insulin would be required to result in 99% of the receptors having bound insulin? (show calculation)
A chemist working for a drug company synthesizes four molecules that bind to the androgen receptor. You carry out a quantitative binding assay for each of these compounds using a purified androgen receptor preparation and determine the following K_d values for the compounds: 1 Times 10^-3 M 1 Times 10^-6 M 2.5 Times 10^-7 M 1 Times 10^-10 M Which of the compounds has the greatest affinity for the androgen receptor? The K_D for binding of insulin to its receptor on liver cells is 6 Times 10^-10 M, and the ambient blood concentration of insulin in liver tissue is 3 Times 10^12 M. What percent of insulin receptors on these liver cells will have bound insulin? (show calculation) If the insulin concentration increases 10-fold (to 3 Times 10^-11 M), what percentage of insulin receptors on these liver cells will have bound insulin?(show calculation) What minimum concentration of insulin would be required to result in 99% of the receptors having bound insulin? (show calculation)
