a.Given the information about changes in clearance and volumeof distribution in pregnancy, and renal disease (RD), predict thecorresponding changes in volume of distribution and half-life inthe same populations.
Write the equations you used to make your decision:
b.Calculate total body clearance for a normal adult (70 kg) inmL/min and L/hr:
c.Calculate renal clearance for a normal adult (70 kg) inmL/min and L/hr:
d.Calculate renal filtration clearance for cefazolin (assumenormal adult)
e.Does the drug cefazolin undergo renal secretion? Why?
f.Calculate the rate of excretion in mg/hr when the plasmaconcentration of cefazolin is 0.2 mg/L
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A. The following table reports pharmacokinetic data for the drug Cefazolin. BIOAVAILABILITY (ORAL) (%) URINARY EXCRETION BOUND IN PLASMA CLEARANCE (mL/min/kg) VOL DIST. (U/kg)HALF-LIFE (%) (hours) Cefazolin 590 80 + 16 392 0.95 0.17 0.19 +0.06 22 +0.02 RD LRDP RD HRD Pency You reported. Following a single 1-9 IV (model-fitted) or IM dose to healthy adults. Reference: Scheld WM, et al, Moxalactam and cefazolin: comparative pharmacokinetics in normal subjects. Antimicusab Agents Chemother, 1981, 79:613-610 a. Given the information about changes in clearance and volume of distribution in pregnancy, and renal disease (RD), predict the corresponding changes in volume of distribution and half-life in the same populations. Renal Disease Pregnancy Volume of Distribution 1 > 个 수 Elimination Half-life 1 1
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