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(A) Interpretation of drug action at the neuromuscular junction The traces below show the evaluation of drug action at the neuromuscular junction using the sciatic nerve tibialis anterior muscle preparation. This is a widely used method for investigating the pharmacological action of neuromuscular agents. Electrical stimulation was carried out for 50 ms duration at 0.15 Hz via bipolar electrodes. In order to determine the type of pharmacological block that is triggered by the novel drugs X1 and X2, 0.1 mg of these substances (per kg body weight) were injected intravenously and then their effect on the contractile pattern of the tibialis anterior muscle measured. The findings are presented as traces and the peaks correspond to contractions of the skeletal muscle, which are evoked by stimulating the sciatic nerve at a frequency of 0.15 Hz. Change in twitch tension after injection of Drug X1: 1.00 kg 0.75 -0.50 0.25 0.00 Ñ‚ Interpretation of the physiological effects of Drug X1 on skeletal muscle contraction patterns (10 marks): What type of drug action caused this physiological effect (agonist vs antagonist)? Can this drug action be reversed by an anti-acetylcholinesterase drug? Drug X1: Change in twitch tension after injection of Drug X2: 1.00 kg 0.75 0.50 0.25 D 0.00 t Interpretation of the physiological effects of Drug X2 on skeletal muscle contraction patterns (10 marks): What type of drug action caused this physiological effect (agonist vs antagonist)? Can this drug action be reversed by an anti-acetylcholinesterase drug? Drug X2: I Discussion of drug action at the neuromuscular junction (40 marks) English (United States) Accessibility Investigate
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