In phase-1 clinical trial, a new antibiotic is being tested inan adult person. The antibiotic has the following pharmacokineticparameters: Clearance = 100 L/hour, Vd 50 L, t½ = 3 hours. If thedrug has to be administered intravenously, what dose should begiven to quickly obtain a plasma concentration of 10 mg/L?
(Visited 4 times, 1 visits today)
Related posts:
- Question: An Antibiotic Was Infused With A 40-mg IV Dose Over 2 Hours. Ten Hours Later, A Second Dose Of 40 Mg Was Infused, Again Over 2 Hours. (a) What Is The Plasma Drug Concentration 2 Hours After The Start Of The First Infusion? (b) What Is The Plasma Drug Concentration 5 Hours After The Second Dose Infusion Was Started? Assume K = 0.2 Hr-?, V= 10 L For The …
- Question: 1) The Half-life And Volume Of Distribution Of An Antibiotic Are 9.51 H And 21.63 L, Respectively. A Patient Was Given An IV Bolus Dose Of 171.46 Mg Of This Antibiotic. Please Calculate The Plasma Drug Concentration 8.23 H After The IV Injection. 2) Following An IV Bolus Dose Of An Anticoagulant, The Plasma Drug Concentration Was Measured As 5.72 Mg/L, …
- Question: Assume The Same Drug As Above (ie, K = 0.2 Hr“), Vp = 10 L) Was Given By Multi- Ple IV Bolus Injections And That At A Dose Of 100 Mg Every 6 Hours For 6 Doses. What Is The Plasma Drug Concentration 4 Hours After The 6th Dose, If The 5th Dose Were Given An Hour Late? Substitute Into Equation 8.26 For All Unknowns: K = 0.2 Hr“), V = 10 L, D = 100 …
- Question: Time (hours) Drug Drug Concentration In Concentration In Plasma Jurine (ug/ml) (ug/ml) 0 1 120 350 2 100 240 4 4. 73 180 6 56 110 12 28 52 18 13 20 24 16 7 30 3 35 1.5 1 40 10.9 0.4 Question 12 1 Pts What Is The Area Under The Curve From Time 6 Hour To 12 Hour For The Plasma Data? 125 110 172 242 Question 13 1.5 Pts What Is The Concentration At Time …
- Question: Homework: 1. 100 Mg Of Drug Is Given Orally Every 6 Hours To A 70 Kg Patient. The Bioavailable Fraction After Oral Dosing Is 50%. The Drug Has A Half Life Of 6 Hours. The Plasma Level Of The Drug When First Administered Is 1.02 Mg/liter. How Long Will It Take To Achieve A Plasma Concentration Of 0.51mg/liter.
- Question: Procainamide Case Procainamide Is Used For The Treatment Of Ventricular Tachyarrhythmia. It Is Administered Intravenously, Orally And Intramuscularly, And Its Therapeutic Range Is 4-8 Ug/mL. When A 450 Mg Dose Is Administered Intravenously To A Normal Healthy Subject: . The Elimination Half Life = 3 Hours The Apparent Volume Of Distribution = 2 L/kg …
- Question: Procainamide Is Used For The Treatment Of Ventricular Tachyarrhythmia. It Is Administered Intravenously, Orally And Intramuscularly, And Its Therapeutic Range Is 4-8 Ug/mL. When A 450 Mg Dose Is Administered Intravenously To A Normal Healthy Subject: ◦ The Elimination Half Life = 3 Hours ◦ The Apparent Volume Of Distribution = 2 L/kg When A 500 …
- Question: Drug A Is Low Concentration Of Nicotine Drug B Is Low Concentration Of Caffeine Drug C Is High Concentration Of Caffeine Drug D Is High Concentration Of Nicotine Drug E Is High Concentration Of Ethanol Please Make The Graph Digitally.
- Question: LORAZEPAM The Following Table Reports Pharmacokinetic Data For The Drug Lorazepam. It Is Cleared Primarily By Glucuronidation By UGT2B7 And UGT2B. In LD And RD Patients The Fraction Of Drug Bound To Plasma Protein Decreases VOL DIST. (kg) HALF-LIFE (hours) CLEARANCE (Uminka) B1OAVAILABILITY (ORAL) () URINARY BOUND IN PLASMA (%) EXCRETION 14 15 93 10 …
- Question: 138.The Medical Assistant Should Count The Pulse For How Long To Be Most Accurate? A. 15 Seconds B. 30 Seconds C. 1 Minute D. 2 Minutes 129 Antibiotic Resistance Is Best Prevented By 2. Prescribe More Than One Antibiotic To The Patient. B. Prolong The Antibiotic Treatment. C. Follow The Recommended Dose And Duration Of The Antibiotic Treatment. D. Increase …
