Question: The Dose Of Sulfisoxazole (Gantrisin, Roche) Recommended For An Adult Female Patient (age 26 Years, 63 Kg) With A Urinary Tract Infection Was 1.5 G Every 4 Hours. The Drug Is 85% Bound To Serum Proteins. The Elimination Half-life Of This Drug Is 6 Hours And The Apparent Volume Of Distribution Is 1.3 L/kg. Sulfisoxazole Is 100% Bioavailable. A.Calculate ...

The dose of sulfisoxazole (Gantrisin, Roche) recommended for an adult female patient (age 26 years, 63 kg) with a urinary tra

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The dose of sulfisoxazole (Gantrisin, Roche) recommended for an adult female patient (age 26 years, 63 kg) with a urinary tract infection was 1.5 g every 4 hours. The drug is 85% bound to serum proteins. The elimination half-life of this drug is 6 hours and the apparent volume of distribution is 1.3 L/kg. Sulfisoxazole is 100% bioavailable. a.Calculate the steady-state plasma concentration of sulfisoxazole in this patient. b.Calculate an appropriate loading dose of sulfisoxazole for this patient. c.Gantrisin (sulfisoxazole) is supplied in tablets containing 0.5 g of drug. How many tablets would you recommend for the loading dose? d.If no loading dose was given, how long would it take to achieve 95%–99% of steady state?

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