The plasma profiles of codeine (COD) and metabolites for 2individuals (labeled A and B) are shown below. The X-axis is timein hours after an oral dose of codeine. [M=morphine;
C6G=COD-6-glucuronide; M3G = morphine-3-glucuronide; NM(ignore)]. Note the data is shown on a log scale on the Y-axis. (A)Which individual is the poor metabolizer? Explain how you know thisfrom the profiles? (B) Is this a problem for cough suppression?Explain.
Transcribed Image Text from this Question
H2C-0. |–CH3 HO Codeine COD 10 000 A B 1000 COG COD 100 M3G Plasma concentration (nmol l-?) O MOG 10 NM M 0 10 20 30 0 10 20 30
(Visited 4 times, 1 visits today)