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Procainamide Case Procainamide is used for the treatment of ventricular tachyarrhythmia. It is administered intravenously, orally and intramuscularly, and its therapeutic range is 4-8 ug/mL. When a 450 mg dose is administered intravenously to a normal healthy subject: . The elimination half life = 3 hours The apparent volume of distribution = 2 L/kg When a 500 mg procainamide tablet is administered orally to a healthy subject (70 kg), the following parameters were determined from the plasma concentration vs. time curve. The absorption rate constant = 2.8 hr! The fraction of dose absorbed = 85.54% The intercept of the plasma concentration time curve = 3.33 ug/mL Procainamide Case 6. If two 500 mg procainamide tablets are given to a 70kg patient with normal absorption and clearance functions every 6 hours, calculate Peak and trough concentration at the steady state Average plasma concentration at the steady state 7. In a 70 kg patient with renal impairment, the elimination half life of procainamide is reported to be 14 hours, but the absorption rate is not affected. What would be the maintenance and loading doses to keep the plasma level above the minimum effective level (4 ug/mL)? Procainamide tablets are available in 250 and 500 mg tablets.
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