1. Answer the following questions usingGraph #1 below. (5 marks total)Key: Blue: Insulin lispro Red: Regular insulin Green: NPH insulin Orange: Insulin glargine Insulin Blood Lovel 6 8 12 14 16 1

Graph #1 Subcutaneous InsulinInjection Time vs Plasma Insulin Blood Level

  1. Which of the following insulins represented in the graph hasthe shortest duration? (1 mark)
  2. Which of the following insulins represented in the graph is thefastest acting? (1 mark)
  3. Which of the following insulins represetend in the graph hasthe longest duration and slowest action? (1 mark)
  4. Order the insulins represtend in the graph from shortestduration, fastest acting to longest duration. (2 marks

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2. Answer the following questions based on graph

Concentration (mg/L) Therapeutic range N 014 One of the 0 2 4 6 8 10 10 12 Time (hr)

  1. Calculate the therapeutic index. (1 mark)
  2. Identify the onset of medication in time. (1 mark)
  3. What happens when the drug drops below the point “x” asidentified on the graph? (2 marks)
  4. What is the duration of action for this medication? (1mark)
  5. What is the minimum effective dose for this medication? (1mark)

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3. answer the following based on the graph

80 % Increase Stroke Volume 40 10 10 100 10 10 HNE Log (Org

a. A pharmaceutical company is testing four agonist drugs forthe treatment of hypertension. Based on the dose response dataillustrated below, which drug studied was the more efficacious? Whywrite the interpretation for your answer?

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Answer the following based on the graph below:

80 А % Increase Stroke Volume D 40 10 10 10 10 100 Log (Drugi

  1. Based on your understanding of drug potency, which if thefollowing drugs is most potent? Why write theinterpretation for your answer

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  1. A group of researchers are conducting a study to screen 1000drug agonists to estimate the most potent antihypertensive agonist.The researcher will use which of the following indicators? Whywrite the interpretation for your answer?
    1. Median Effective Dose (ED50)
    2. Median Lethal Dose (LD50)
    3. Median Toxicity Dose (TD50)
    4. Half Life

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Key: Blue: Insulin lispro Red: Regular insulin Green: NPH insulin Orange: Insulin glargine Insulin Blood Lovel 6 8 12 14 16 18 20 22 24 10 Hours After Injection SubQ Injection Concentration (mg/L) Therapeutic range N 014 One of the 0 2 4 6 8 10 10 12 Time (hr) 80 % Increase Stroke Volume 40 10 10 100 10 10 HNE Log (Org 80 А % Increase Stroke Volume D 40 10 10 10 10 100 Log (Drugi
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