1. Answer the following questions usingGraph #1 below. (5 marks total)
Graph #1 Subcutaneous InsulinInjection Time vs Plasma Insulin Blood Level
- Which of the following insulins represented in the graph hasthe shortest duration? (1 mark)
- Which of the following insulins represented in the graph is thefastest acting? (1 mark)
- Which of the following insulins represetend in the graph hasthe longest duration and slowest action? (1 mark)
- Order the insulins represtend in the graph from shortestduration, fastest acting to longest duration. (2 marks
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2. Answer the following questions based on graph
- Calculate the therapeutic index. (1 mark)
- Identify the onset of medication in time. (1 mark)
- What happens when the drug drops below the point “x” asidentified on the graph? (2 marks)
- What is the duration of action for this medication? (1mark)
- What is the minimum effective dose for this medication? (1mark)
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3. answer the following based on the graph
a. A pharmaceutical company is testing four agonist drugs forthe treatment of hypertension. Based on the dose response dataillustrated below, which drug studied was the more efficacious? Whywrite the interpretation for your answer?
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Answer the following based on the graph below:
- Based on your understanding of drug potency, which if thefollowing drugs is most potent? Why write theinterpretation for your answer
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- A group of researchers are conducting a study to screen 1000drug agonists to estimate the most potent antihypertensive agonist.The researcher will use which of the following indicators? Whywrite the interpretation for your answer?
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- Median Effective Dose (ED50)
- Median Lethal Dose (LD50)
- Median Toxicity Dose (TD50)
- Half Life