Question: Scopolamine Was Administered To A Patient As An Oral Tablet At A Dose Of 0.40 Mg. Blood Samples Were Collected And The Plasma Scopolamine Concentration (Cp) Determined At Various Time Points (t): Cp Reference Residuals (pg/mL) Line Using The Method Of Residuals And Assuming A One- Compartment Model, Plot The Data (including Residuals Plot) And Estimate …

Scopolamine was administered to a patient as an oral tablet at a dose of 0.40 mg. Blood samples were collected and the plasma scopolamine concentration (Cp) determined at various time points (t): Cp Reference Residuals (pg/mL) Line Using the method of residuals and assuming a one- compartment model, plot the data (including residuals plot) and estimate the following PK parameters: 40 Time (h) 0.1 0.3 0.4 0.5 80 91 106 85 60 23 1 a) the Tmax: b) the Cmax: the Ke value d) the elimination half-life e) the Ka value f) the absorption half-life 2 4 Show all your work.