TL is a 62-year-old male who was in a car crash andwho has been hospitalized for compartment syndrome from a left legcrush injury. He has areas of necrosis (tissue ischemia) seen alonghis calf. Tissue necrosis is areas of dead cells. It is imperativethat the necrosis does not increase.
1. Discuss the following etiologies of cellularinjury and death and what can be done for TL to maximize hiscare.
a. Ischemiaand hypoxic injury
b. Nutritionalinjury
c. Infectiousand immunologic injury
2. Why is an increase in intracellular calciuminjurious?
3. Why is apoptosis significant?
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