Question: 1)The p-value corresponding to the chi-square test of
independence on alleles is 0.004. If there …



1)The p-value corresponding to the chi-square test of
independence on alleles is 0.004. If there are a total of 50 SNPs
in the data set, the Bonferroni corrected p-value is?

2)What is the goal of association mapping?

3)Applying the chi-square test of independence to case and control
genotypes at five SNPs (labeled SNP01, SNP02, SNP03, SNP04, SNP05),
yields the respective p-values 0.05, 0.04, 0.009, 0.004, and 0.10.
The genetic phenotype is Fructosia.

After Bonferroni correction for multiple testing, what SNPs are
declared to be significantly associated with Fructosia at the 5%
significance level?

4)In what 10-year period did researchers develop technologies for
genotyping Single Nucleotide Polymorphisms?

5)What is the Chi-square test on independence for genotypes value
for the following contingency table?

Phenotype A1A1 A1A2 A2A2
Case 50 100 50
Control 50 100 50

6) In a GWAS with 500,000 SNPs tested among cases and controls,
one SNP has a chi-square test-statistic p-value of 0.000001. After
Bonferroni correction, is this SNP’s p-value significant at the
0.05 level?

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