2. Answer the following questions about pharmacodynamics
A drug has a favorable therapeutic index when studied in apopulation of people with normal BMI. When studied in a populationof obese individuals the ED50 values for the therapeutic and toxiceffects are similar to the normal population, but the populationvariance in these responses increase dramatically.
a. What would the quantal dose-response plots look like forthese two populations?
b. What about the slope of the dose-response plots?
c. What is the effect on therapeutic index?
d. How might the certain safety factor (CSF) change?
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