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2. Fatimah LC Jackson states “the genetic composition of present-day human populations is determined largely by the interactions between the human host and infective agents”. A. Why is some of the most complete evidence for role of infectious disease on human biological variation found in the context of malarial environments? B. Discuss three lines of evidence suggesting an association between hemoglobin variants and malaria C. Where and when did the sickle-cell allele first appear in equatorial Africa? What conditions led to selection for sickle cell allele in this ecological niche and illustrate how we might apply a biocultural model to understand these relationships. D. How could current dietary components potentially influence the longstanding balance of selective pressures?
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