Question: 3. Answer The Following Questions About Pharmacodynamics A. Polymorphisms In CYP2D6 Results In 3 Populations: Ultra-rapid, Extensive And Poor Metabolizers. Compare The Quantal Dose-response Plots If Drug Z, Which Is Extensively Metabolized By CYP2D6, Is Administered To Each Of These 3 Homogeneous CYP2D6 Populations As Well As A Heterogeneous Mixed Population….

3. Answer the following questions about pharmacodynamics

a. Polymorphisms in CYP2D6 results in 3 populations:ultra-rapid, extensive and poor metabolizers. Compare the quantaldose-response plots if Drug Z, which is extensively metabolized byCYP2D6, is administered to each of these 3 homogeneous CYP2D6populations as well as a heterogeneous mixed population. What aboutthe therapeutic index and certain safety factor?

b. Explain how a positive allosteric modulator could increasethe duration of action of an agonist at the orthosteric site

c. How would an increase in clearance affect the duration ofaction of a drug if:

(1) kelim<< koff

(2) kelim>>koff