4. Pharmacodynamics: Plot the concentration-response plot for aninverse agonist in the presence of a fixed concentration of anagonist when:

  1. Basal activity is very low
  2. Basal activity is high

5. In question 4 above what would be the effect of

  1. Increasing the KD for the inverse agonist
  2. Decreasing the efficacy of the inverse agonist
  3. Increasing the bioavailability of the inverse agonist after POadministration
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