A 60-year-old male presents to his general practitioner (GP)complaining of shortness of breath and lower limb swelling. Thishas developed over the last 3 days. He has a history of poorlycontrolled type 2 diabetes, hypertension and chronic kidneydisease. On examination, there are bi-basal crepitations andbilateral pitting oedema to the tibial tuberosity. Urine dipstickis 3+ positive for protein.

A)   What is thedefinition of chronic kidney disease? Describe how it isclassified.

B)

What complication of chronic kidneydisease has caused this patient’s presentation?

– List three other possible complications of chronickidney disease.
-Outline four investigations to screen for/diagnose thesecomplications including rationale.

C) Name two types of renal replacement therapy and foreach discuss two advantages and two disadvantages.

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