Transcribed Image Text from this Question
A lethal dose (LD) is an indication of the lethality of a given substance usually recorded as dose per kilogram of subject body weight. Because resistance varies from one individual to another, the most commonly used lethality indicatoris the LDso a dose at which 50% of subjects will die. LD, values for humans are generally estimated by extrapolating results from testing on animals or on human cell cultures. Ethylene glycol is a toxic substance commonly used for antifreeze in automobiles. Due to its sweet taste, children and animals would sometimes consume large quantities of it if given access to the antifreeze. Upon Ingestion, ethylene glycol and its toxic byproducts in our body first affect the central nerve system, then the heart, and finally the kidneys. Ingestion of sufficient amounts can be lethal. Data set of mice body weights and respective LDso for ethylene glycol were obtained from an experiment as follows: Body weight of Amount of ethylene glycol administered to mice mouse, X (8) at which 50% of the population died, Y (mg) QUESTION 100 200 1. Assuming we can extrapolate this 200 300 experimental data from mice to humans, 300 400 what would the LDs (in the unit of g/kg) 400 500 for humans be according to the 500 550 X-Y plot of the data? (Hint: 1 g = 10kg and 1 mg = 10 g) 600 700 700 800 II. A three year old boy whose body 800 900 weight is 30 kg accidentally drank 900 950 40 g of antifreeze left in the garage. Do you think this poor boy probably 1000 1200 died or not? 1100 1300 The LD 506 kg for your answer ne in a number this two after the company If the boy did type of the boy didnt types than
(Visited 2 times, 1 visits today)
