Question: A typical cellular response of a mammary epithelial cell to the k_0 for the Interaction between E…
Show transcribed image text A typical cellular response of a mammary epithelial cell to the k_0 for the Interaction between EGF and its receptor is 1 Times 10^-10 M. Let's Imagine that at least 25% of the receptors on a normal cell must be engaged by EGF in order to trigger the celluar proliferation response. What miminum concentration of EGF is required to induce cell proliferation? (show calculation) Mammary epithellal cancer cells have amplified levels of EGF receptors on their surface. If such a cell has 1000 EGF receptors, as compared to 200 rcceptors on a normal cell, what minimum concentration of EGF is required to Induce cell proliferation in the cancer cell? [show calculation; note that the same number of receptors (not percentage) must be activated to promote proliferation In normal or cancer cells] The ambient (unstimulated) concentration of EGF in mammary epithelial tissue is 1 Times 10^-10 M. Will this level of EGF stimulate proliferation in normal mammary epithelial cells? Will this level of EGF stimulate proliferation in mammary epithelial cancer cells? You produce a competitive inhibitor for the EGF receptor that has a K_d = 0.4 times 10^-11 M. What concentration of the inhibitor will be required to block 50% of the EGF receptor activity in the mammary epithelial cancer cells? (show calculation)
A typical cellular response of a mammary epithelial cell to the k_0 for the Interaction between EGF and its receptor is 1 Times 10^-10 M. Let's Imagine that at least 25% of the receptors on a normal cell must be engaged by EGF in order to trigger the celluar proliferation response. What miminum concentration of EGF is required to induce cell proliferation? (show calculation) Mammary epithellal cancer cells have amplified levels of EGF receptors on their surface. If such a cell has 1000 EGF receptors, as compared to 200 rcceptors on a normal cell, what minimum concentration of EGF is required to Induce cell proliferation in the cancer cell? [show calculation; note that the same number of receptors (not percentage) must be activated to promote proliferation In normal or cancer cells] The ambient (unstimulated) concentration of EGF in mammary epithelial tissue is 1 Times 10^-10 M. Will this level of EGF stimulate proliferation in normal mammary epithelial cells? Will this level of EGF stimulate proliferation in mammary epithelial cancer cells? You produce a competitive inhibitor for the EGF receptor that has a K_d = 0.4 times 10^-11 M. What concentration of the inhibitor will be required to block 50% of the EGF receptor activity in the mammary epithelial cancer cells? (show calculation)
