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Antibiotics case Patient CS is a 35-year-old male weight 76.6 kg. The patient is to be given multiple IV bolus injections of an antibiotic every 6 hours. The effective concentration of this drug is 15 ug/mk. After the patient is given a single IV dose, the elimination half-life is determined to be 3.0 hours and the apparent volume of distribution if 196 ml/kg. After the condition of this patient has stabilized, the patient is to be given the drug orally. The oral antibiotics has 90% bioavailability. The physician would like to continue oral medication every 6 hours. The oral antibiotics is available only in 125-, 250- and 500 mg tablets. Please answer the following questions: 1. What is the dose for the multiple IV dose regimen? 2. What is the dose for the multiple PO dose regimen? 3. What combination of oral tablets would be given to the patient? 4. If the patient can only take one tablet, which oral tablet should be given? Is there a need to adjust dosing interval?
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