Question: Assume The Same Drug As Above (ie, K = 0.2 Hr“), Vp = 10 L) Was Given By Multi- Ple IV Bolus Injections And That At A Dose Of 100 Mg Every 6 Hours For 6 Doses. What Is The Plasma Drug Concentration 4 Hours After The 6th Dose, If The 5th Dose Were Given An Hour Late? Substitute Into Equation 8.26 For All Unknowns: K = 0.2 Hr“), V = 10 L, D = 100 …

Assume the same drug as above (ie, k = 0.2 hr“), Vp = 10 L) was given by multi- ple IV bolus injections and that at a dose of 100 mg every 6 hours for 6 doses. What is the plasma drug concentration 4 hours after the 6th dose, if the 5th dose were given an hour late? Substitute into Equation 8.26 for all unknowns: k = 0.2 hr“), V = 10 L, D = 100 mg, n = 6, t = 4 hr, T = 6 hr, t-miss = 6 + 4 = 10 hr, tactual = 9 hr (taken 1 hour late, ie, 5 hours before the 6th dose).