Question: Bee venom contains phospholipase A2, which is responsible for some of the inflammatory effec…

venom contains
phospholipase A2,
which is responsible for some of the inflammatory effects of a bee
sting. A schematic drawing of the actice site is shown below.
Notice the aspartate and histidine residues in the active site, as
well as the positions of the water molecule. Based on what you have
learned about protease mechanisms, propose a chemical mechanism for
the phospholipase A2
reaction. In your
answer show Ca2+,
Gly10,
His34
and
Asp64
at each step; the
other residues do not need to be included in your answer.
IMPORTANT:
Each step in your
mechanism should be enclosed in a box. Answers must be neatly
drawn;