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Clinical scenario Sun is a medical college student, 22 years old. As the grade increased, the academic str ess increased. For the last 3 months, Sun found her hair was falling out more and more with the increased probability of insomnia. She complained to you that she was on the verge of breakdown for not having good sleep, and asked suggestion from you. As her best friend, you have to give her your best advise based on EBM. Now, you follow these steps to finish your job. 1 1. Construct a well-built clinical question Based on this scenario. Choose the best, well built clinical question. 5 ( ) A. How to save a 22 years old medical college student from the verge of breakdown? B. How to help a 22 years old medical college student to relieve the academic stress? C. What alternatives will be helpful in stopping Sun’s alopecia? D. What treatments can best relieve early insomnia? 2. Select the appropriate resource and conduct a search, choose the best search strate gy to a d d r es S the question. 5 ( ) A. Search: alopecia AND (treatment OR drug OR therapy), Limits: Randomized Controlled Trial B. Search: insomnia AND (treatment OR drug OR therapy), Limits: Randomized Controlled Trial C. Search: insomnia AND academic stress, Limits: Randomized Controlled Trial D. Search: (alopecia AND insomnia) AND (treatment OR drug OR therapy), Limits: Rando mized Controlled trial 3. Appraise the evidence for its validity (closeness to the truth) and its applicability (us efulness in clinical practice) Read the following article to determine if the article meets the criteria for validity. As state d previously, evaluating the medical literature is a complex undertaking. You will find that the answers to the questions of validity may not always be clearly stated in the article an d that you may have to use your own judgment about the importance and significance of each question. Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well- being, and Sleep-Related Quality of Life: A Randomized Clinical Trial 4 doi: 10.1001/jamapsychiatry.2018.2745 PMID: 30264137 Answer these questions and supply a short explanation. Are the results valid? 1. Randomization: Were patients randomized? 3′ 2. Blinding: To what extent was the study blinded? 3′ 3. Follow-up: Was follow-up complete? 4′ 4. Was the trial stopped early? 4′ About the results 5. How large was the intervention effect? 4 6. How precise was the estimate of the intervention effect? 4 7. What were the confidence intervals? 4′ Apply the results to patient care. 8. Were the study patients similar to my population of interest? 4′ 9. Were all clinically important outcomes considered? 4′ 10. What were the primary and secondary endpoints studied? 4′ 11. Are the likely treatment benefits worth the potential harm and costs? 4′ 12. Is the reduction of clinical endpoints worth the increase of cost and risk of harm? 4′ 4. Return to the patient — integrate the evidence and clinical expertise, patient prefere nces and apply it to practice What suggestion would you discuss with Sun? 12
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