Question: During the biosynthesis and transport of collagen from the
endoplasmic reticulum throught he Golg…
During the biosynthesis and transport of collagen from the
endoplasmic reticulum throught he Golgi apparatus to the cell
surface, collagen fibrils form extracellularly rather than
intraceullularly. Which of the following does NOT
help to explain why this happens?
A) Type I procollagen synthesized in cels contains nonhelical
segments at each end of the polychain that limit their ability to
oligomerize into collagen fibrils.
B) Procollagen must be soluble and small enough to fit within
the intracellular transport machinery.
C) Type I procollagen cannnot form the triple helical oligomers
that are the core structure of any collagen oligomer
D) Type I procollagen contains hydroxylated proline and lysine
residues that prevent polypeptide chain oligomerization within the
cell