Question: How is CXCR2 inserted into the ER Membrane? What are the major
proteinsresponsible for this proce…
How is CXCR2 inserted into the ER Membrane? What are the major
proteinsresponsible for this process (ER targeOng, protein
translocaOon, etc.)
How is this process di?erent than
protein translocaOon to the mitochondria or
nucleus? How is it similar?
Show transcribed image text Characterized IL-8 signaling pathways. VEGFR EGFR 1L-8 IL-8 CXCR1/2 XGR1/2 CdC42 GTPase RhoGTPase RacGTPase Cytoskeleton P13- Dynamics RasGTP Focal Adhesion Assembly Calcium PKC) mobilization Raf Mek Akt FAK Src → Paxillin →. mTOR Erk1 S6K Actin Nucleation S6 PKC p38 Ak Protein Translation i.-' ERK HIF-1 Angiogenesis Cell survival Cell proliferation Cell proliferation Cell proliferation Cell proliferation Gene NF-KB AP-1 AR STAT3 β-catenin Cell survival Angiogenesis Cell survival Cls Cell metabolism Invasion Cell survivalCell survival Expression survival Cell survival Expression Angiogenesis CCR Molecular Pathways
Characterized IL-8 signaling pathways. VEGFR EGFR 1L-8 IL-8 CXCR1/2 XGR1/2 CdC42 GTPase RhoGTPase RacGTPase Cytoskeleton P13- Dynamics RasGTP Focal Adhesion Assembly Calcium PKC) mobilization Raf Mek Akt FAK Src → Paxillin →. mTOR Erk1 S6K Actin Nucleation S6 PKC p38 Ak Protein Translation i.-' ERK HIF-1 Angiogenesis Cell survival Cell proliferation Cell proliferation Cell proliferation Cell proliferation Gene NF-KB AP-1 AR STAT3 β-catenin Cell survival Angiogenesis Cell survival Cls Cell metabolism Invasion Cell survivalCell survival Expression survival Cell survival Expression Angiogenesis CCR Molecular Pathways
