Question: Imagine a situation in which the number of urea leak channels
increased dramatically in the ascen…



Imagine a situation in which the number of urea leak channels
increased dramatically in the ascending limb of the loop of Henle.
What could be one likely consequence of this situation?

The increased solute concentration in the vasa recta would
stimulate additional water reabsorption.
The final urine output would increase greatly because of the
increase in ADH-regulated water reabsorption.
Aldosterone-regulated Na+ pump activity would
increase dramatically to stabilize the osmotic concentration
gradient.
The concentration gradient of the renal medulla would remain
unaffected.

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