Question: IV/PO Conversion-Theophylline 1 A Patient To Be Discharged From The Hospital Has Been Receiving Aminophylline 40 Mg/hr By IV Infusion. Upon Discharge, The Physician Wants To Switch The Patient To Theophylline Tablets. The Pharmacist Recognizes That Theophylline Tablets Have 85% Bioavailability. What An Oral Regimen Is Appropriate For This Patient? Extended …

IV/PO Conversion-Theophylline 1 A patient to be discharged from the hospital has been receiving aminophylline 40 mg/hr by IV infusion. Upon discharge, the physician wants to switch the patient to theophylline tablets. The pharmacist recognizes that theophylline tablets have 85% bioavailability. What an oral regimen is appropriate for this patient? Extended Release, 12 HR: 100, 200, 300, 450 mg tablets Extended Release, 24 HR: 400, 600 mg tablets NH2 ‘N H2N Theophylline MW=180 2. Aminophylline IV/PO Conversion-Theophylline 2 An adult male asthmatic patient has been maintained on an IV infusion of aminophylline in the hospital. The steady state aminophylline concentration was 8 ug/mL and total body clearance was 3.0 L/hr. When the patient is discharged, the physician wishes to switch him to oral dosing, but maintain the same plasma concentration. What is an appropriate oral dosage regimen for this patient.