Need help With parts 2 and 3

For the first part of the activity, let’s “run” a TLC plate thatjust has pure active ingredients found in many analgesics. Use theTLC plate pictured below along with the provided measurements todetermine the Rf value for each active ingredient. Note that thecolors don’t mean anything; they’re only for aesthetics. A table isalso provided to organize your information.

Letter (TLC)

Active Ingredient

Distance Traveled (cm)

Rf Value

A

Acetylsalicylic acid (aspirin)

2.2

.42

B

Ibuprofen

4.0

.77

C

Caffeine

.65

.13

D

Acetominophen

1.9

.37

E

Naproxen sodium

3.1

.60

Solvent Front

5.2

Now that you have Rf values, you can use them to experimentallydetermine the active ingredients found in common brands ofanalgesics. Similar to Part 1, a table is provided to help you stayorganized. A few analgesics show more than one spot. This isexpected, since many analgesics have more than one activeingredient.

Letter (TLC)

Distance Traveled (cm)

Analgesic Brand

Rf Values

Identity of Active ingredient(s)

A

2.9

Aleve

.60

B

1.8

.60

Midoll

?

C

2.0

Bayer

.42

D

3.7

Advil

.77

E

1.7

Tylenol

.35

F

1.9

1.8

.58

Excedrin

?

G

1.8

Motrin

.38

Solvent Front

4.8

Now, it’s time to use the knowledge you gained in Parts 1 and 2to identify the unknown analgesic brought in with the patient.Using the information below, identify the unknown.

Solvent: 5.4

Unknown: 2.0

Based on your TLC experiment, which analgesic did your patientlikely take? Thoroughly explain how you got your answer using thedata provided.

If the patient mentioned at the beginning of the activity wasjaundiced and their spouse indicated that the patient had not beeneating or drinking much, would these symptoms also suggest youranswer to #1?

Another analgesic that has a bit of a cult following is BCPowder. Search for the active ingredients of this analgesic usingyour favorite search engine. Based on the active ingredients, ifyou performed the same experiment (Part 2) on BC powder, what wouldyou expect to observe?

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