Question: Next, investigators examined the role of FGF21 in coordinating the response to LP diet. To do so …
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Show transcribed image text Next, investigators examined the role of FGF21 in coordinating the response to LP diet. To do so they used mice that did not express FGF21 (Fgf21 KO) and compared how these animals responded to the low-protein diet relative to the wild-type (WT) animals. The upper figure below indicates the energy expenditure (in kcal/hr) dependent on genotype (WT vs. KO) and diet (Control or IP). The lower figure indicates the total dietary intake (in kcal/day) over 14 days of dietary treatment in the WT and Fgf21 KO animals. In the space to the right of the figure (and/or in the space below), describe the results from the two figures above. You can assume that asterisks are indicative of significant differences within a genotype. What is the purpose of using the KO animals in this study? Be as specific as you can in your response.
Next, investigators examined the role of FGF21 in coordinating the response to LP diet. To do so they used mice that did not express FGF21 (Fgf21 KO) and compared how these animals responded to the low-protein diet relative to the wild-type (WT) animals. The upper figure below indicates the energy expenditure (in kcal/hr) dependent on genotype (WT vs. KO) and diet (Control or IP). The lower figure indicates the total dietary intake (in kcal/day) over 14 days of dietary treatment in the WT and Fgf21 KO animals. In the space to the right of the figure (and/or in the space below), describe the results from the two figures above. You can assume that asterisks are indicative of significant differences within a genotype. What is the purpose of using the KO animals in this study? Be as specific as you can in your response.
