Question: One consequence of an individual who has compound heterozygosity at the CFTR locus i s (2) if the…
Show transcribed image text One consequence of an individual who has compound heterozygosity at the CFTR locus i s (2) if the individual has children all the children will be affected the parents will most likely have CF as well the condition will be more difficult to diagnose any drug that might effectively treat one allele will probably not affect another If a PCR amplified sample hybridizes with two allele specific probes, one normal and one mutant sequence, a carrier identified if (3) both probes give a signal. neither sample gives a signal. only the mutant probe gives a signal. only the non-mutant probe gives a signal. None of the choices is correct. The classical form of the metabolic disease phenylketonuria is caused by a mutation in the gene encoding the enzyme phenylalanine hydroxylase (PAH), which converts phenylalanine to tyrosine. A variant form of phenylketonuria is caused by a mutation in a separate gene that encodes a different enzyme involved in the synthesis of a cofactor needed for PAH to function. Which of the following phenomena is illustrated by these two forms of phenylketonuria>(2) Nonanonymous polymorphism Allelic heterogeneity Compound heterozygosity Locus heterogeneity Anonymous polymorphism
One consequence of an individual who has compound heterozygosity at the CFTR locus i s (2) if the individual has children all the children will be affected the parents will most likely have CF as well the condition will be more difficult to diagnose any drug that might effectively treat one allele will probably not affect another If a PCR amplified sample hybridizes with two allele specific probes, one normal and one mutant sequence, a carrier identified if (3) both probes give a signal. neither sample gives a signal. only the mutant probe gives a signal. only the non-mutant probe gives a signal. None of the choices is correct. The classical form of the metabolic disease phenylketonuria is caused by a mutation in the gene encoding the enzyme phenylalanine hydroxylase (PAH), which converts phenylalanine to tyrosine. A variant form of phenylketonuria is caused by a mutation in a separate gene that encodes a different enzyme involved in the synthesis of a cofactor needed for PAH to function. Which of the following phenomena is illustrated by these two forms of phenylketonuria>(2) Nonanonymous polymorphism Allelic heterogeneity Compound heterozygosity Locus heterogeneity Anonymous polymorphism
