pharmacology
PLEASE I NEED URGENT HELP IN QUESTION
i need summary including aim or purpose and procedure andevalution about each method involved in vivo and vitro mthod ofscreening of analgesic agents
pharmacology
i meant i need a little introduction about each methodinvolved in vivo and vitro method about screening of analgesicagents and that introduction should include purpose and procedureand evalution about each method involved for example in vivo methodwe have four categroies for example categrorie A we have 4 exampleswe should write about each one aim and purpose and evalution ofeach method .
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SCREENING METHODS Screening of analgesic agents include IN-VIVO METHOD A) Pain-state models using Thermal stimuli The tail-fick model using radiant heat/ Immersion of the tail in hot water. Paw-withdrawal test. Hot-plate test. Pain-state models using Cold-stimuli B) Pain-state models using Mechanical stimuli Strain gauges Von-Fray filaments. Inclined plane test. Pain-state models using Electrical stimul Electrical stimulation of the sail Grid-shock test. Stimulation of the tooth pulp Monkey-shock titration test. Stimulation or the time D) Pain-state models using Chemical stimull Formalin test. Acetic acid induced writing test. Stimulation of hollow organs – IN VITRO METHOD Bioassay of nociceptin. Recetptor binding of nociceptin CH-naloxone binding assay DH-bremszocine binding assay. Cannabinoids binding assay Inhibition of Enkcephalinase. 7 of 1 IN-VITRO METHOD A. Bioassay of nociceptin. B. Recetptor binding of nociceptin. C. 3H- naloxone binding assay. D. 3H- bremazocine binding assay. E. Cannabinoids binding assay. Inhibition of Enkephalinase. F. SCREENING METHODS • Screening of analgesic agents include IN-VIVO METHOD A) Pain-state models using Thermal stimuli The tail-flick model using radiant heat/ Immersion of the tail in hot water. Paw-withdrawal test. . Hot-plate test. iv. Pain-state models using Cold-stimuli B) Pain-state models using Mechanical stimuli Strain gauges. Von-Frey filaments Inclined-plane test. C) Pain-state models using Electrical stimuli Electrical stimulation of the tail Grid-shock test. i Stimulation of the tooth pulp Monkey-shock titration test. Stimulation of the limbs. D) Pain-state models using Chemical stimuli Formalin test. Acetic acid induced writing test. . Stimulation of hollow organs
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