Question: Signal Transduction Overview a.What is the general paradigm for activation of signal transduction…

Signal Transduction Overview

a.What is
the general paradigm for activation of signal transduction pathways
for RTKs (receptor tyrosine kinases?

b.What are
the MULTIPLE roles that arrestin plays in GPCR-mediated
signal transduction pathways?

c.Explain
the role of so-called SH2 and SH3 domains in signaling

d.Outline
the mechanism for receptor-mediated endocytosis, and the functional
consequences, comparing the consequences for a nutrient-trafficking
receptor ( eg LDL receptor), a GPCR, and a Growth factor
receptor

e.Give ONE
detailed example of how information from OUTSIDE of the cell gets
transduced, via activation of a cell surface receptor of your
choice, to altered transcription of a set of genes in the
nucleus.