T.I is a 41-year-old, who weighs 70 kg, male, with an SrCr of 1mg/dL, was prescribed gentamicin 140 mg IV every 8 hours. Aftersteady state had been achieved, a trough concentration of 0.7 mg/Lwas obtained just before a dose, and a peak level of 4 mg/L wasobtained two hours after the end of the infusion, which lasted for30 minutes.
Does T.I.’s dose or dosing interval need to be adjusted sincethe peak concentration was at the lower end of the usual target of4 to 8 mg/L?
(Visited 4 times, 1 visits today)
Related posts:
- Question: A Peak And Trough Level Was Obtained From A Client Receiving An Aminoglycoside Iv Piggy Back Every 8 Hours. Which Finding Presents The Highest Risk For The Patient A. Decreased Peak Only B. Decreased Trough Only C. Increased Trough And Peak D. Decreased Peak And Trough
- Question: R.J. Was Started On Tobramycin 140 Mg IV Over 30 Mins Every 8 Hr. A Trough Tobramycin Level Of 1.5 Mg/L Was Taken Before The Start Of The Fourth Dose And A Subsequent Peak Level Was Obtained As 3 Mg/L, 30 Mins After The End Of The Half-hour Infusion. What Are The Revised PK Parameters For R.J. And Are The Revised Parameters Reasonable?
- Question: Jane Doe , A 40-year-old, 60 Kg, Non-obese Female With A SrCr Of 1 Mg/dL, Is Started On Gentamicin 300 Mg Infused Over One Hour Daily. Calculate The Expected Steady-state Peak Concentration At The End Of The One-hour Infusion, At 12 Hours After Starting The Infusion, And At The Trough. Please Show The Steps
- Question: If A Drug Is Dosed Once Every 2 Half-lives, The Peak To Trough Ratio Will Be Approximately 4:1. Answers A – B A True B False Total Concentrations At Steady State Can Be Used To Determine What Is Happening With Free Concentrations At Steady State As Long As The Plasma Protein Binding Has Not Changed Answers A-B A True Fale
- Question: An Antibiotic Was Infused With A 40-mg IV Dose Over 2 Hours. Ten Hours Later, A Second Dose Of 40 Mg Was Infused, Again Over 2 Hours. (a) What Is The Plasma Drug Concentration 2 Hours After The Start Of The First Infusion? (b) What Is The Plasma Drug Concentration 5 Hours After The Second Dose Infusion Was Started? Assume K = 0.2 Hr-?, V= 10 L For The …
- Question: 36. At Very High Concentrations — Concentrations Much Higher Than The Drug’s Km–drugs Are More Likely To Approach Zero-order Elimination A. True B. False 37. A Patient, JH, Is Administered Phenytoin Free Acid, 300 Mg/day For 2 Months (assume Steady State Is Achieved), And A Plasma Concentration Determined Just Before A Dose Is 10 M . The Phenytoin …
- Question: Peak Flow Meter: Please Answer The Questions Related To This Patient Case. LB Is A 47 Year-old Female With Asthma. When Diagnosed With Asthma, Her Peak Flow Meter Readings Were: 470 L/min, 500 L/min And 485 L/min 1) Which Of The Readings Would You Use To Determine The Patients PEF? 2) Determine The Patients Green, Yellow And Red. 3) Today, LBs Peak …
- Question: A Pt Is Given Medicine That Releases 30mg Of The Medicine Over 8hrs At A Constant Rate. Hepatic Clearance Half Time Is 2.5hrs.How Long Will It Take Before The Blood Level Concentration Of The Drug Has Risen To 90% Of The Steady State Value After The Medication Is Taken? There Is No Time Delay.
- Question: Question 32 FLAG QUESTION The Volume Of Distribution Of A Drug Has Decreased. What Would You Do To Ensure That There Is No Change In The Css, Avg Or Peak To Trough Ratio The Dose Rate Should Be Increased/decreased Not Changed) And The Dose Interval Should Be 2 (increased/decreased/not Changed) Answers 1.2 1. 3 2
- Question: Question 1 Of 25 A Patient With CD20 Positive, Non-Hodgkin Lymphoma Is Scheduled To Begin Rituximab. The Nurse Knows A. Another Therapy Is Ordered If The Patient Has An Infusion Reaction B. The Risk Of Infusion Reactions Is Decreased Since The Patient Is Chemotherapy-naive C. Most Infusion-related Reactions Occur 24-48 Hours After The Infusion D. Infusion-related…
