Question: The citric acid cycle is a major hub of metabolism How is the citric acid cycle regulated? What…
Show transcribed image text The citric acid cycle is a major hub of metabolism How is the citric acid cycle regulated? What metabolities serve as starting points for the metabolic pathways of fats and proteins? Recent research implicates mis-regulation of the citric acid cycle and development of certain cancers. Do some further reading and write a short paragraph on the topic of hypoxia. Review your textbook (p. 515) on the regulation of hypoxia in cancer cells Propose a new cancer drug and biochemical target based on this information. Electron transport chain. The enzyme succinate dehydrogenase is part of the citric acid cycle (Fig. 17.15) and the electron transport chain (Fig. 18.6). Calculate the free energy (Delta G) of the reaction catalyzed by succinate dehydrogenase under physiological conditions: 2 mM succinate. 0.5 mM fumaratc. 2 mM FAD, and 0.2 mM FADH2. [Recall that Delta G = -n F Delta E_0 See Table 18.1 for the relevant standard reduction potential (Delta E_b).]
The citric acid cycle is a major hub of metabolism How is the citric acid cycle regulated? What metabolities serve as starting points for the metabolic pathways of fats and proteins? Recent research implicates mis-regulation of the citric acid cycle and development of certain cancers. Do some further reading and write a short paragraph on the topic of hypoxia. Review your textbook (p. 515) on the regulation of hypoxia in cancer cells Propose a new cancer drug and biochemical target based on this information. Electron transport chain. The enzyme succinate dehydrogenase is part of the citric acid cycle (Fig. 17.15) and the electron transport chain (Fig. 18.6). Calculate the free energy (Delta G) of the reaction catalyzed by succinate dehydrogenase under physiological conditions: 2 mM succinate. 0.5 mM fumaratc. 2 mM FAD, and 0.2 mM FADH2. [Recall that Delta G = -n F Delta E_0 See Table 18.1 for the relevant standard reduction potential (Delta E_b).]
