Question: The retinoblastoma gene (rb) encodes a protein that inhibits E2F, a transcription factor that act...

Question: The retinoblastoma gene (rb) encodes a protein that inhibits
E2F, a transcription factor that act…

The retinoblastoma gene (rb) encodes a protein that inhibits
E2F, a transcription factor that activates several genes involved
in cell division. Mutations in rb are associated with certain forms
of cancer. Under the following conditions would you expect cancer
to occur?

– Yes/No	Both copies of rb are functional, one copy of E2F is defective.
– Yes/No	One copy of rb is defective, both copies of E2F are functional.
– Yes/No	Both copies of rb are defective, both copies of E2F are functional.
– Yes/No	Both copies of rb are defective, one copy of E2F is defective.
– Yes/No	Both copies of rb and E2F are defective.