Question: Transport of Medication Through Skin For a simplified ease of tranpsort through skin, assume tot…
Show transcribed image text Transport of Medication Through Skin For a simplified ease of tranpsort through skin, assume total diffusional resistance of skin is entirely due to the stratum corneum (see Figure 5.14). This ignores penetration in sweat duets, etc. This would be sufficiently accurate for relatively rapidly penetrating molecules of small molecular weight. Consider application of a solute to the outer surface of stratum corneum which has a thickness of 1 micron. The partition coefficient relating the membrane surface concentration to the concentration of applied material is 1. The inner surface of stratum corneum is assumed to be maintained at essentially zero concentration since the molecules are removed as soon as they reach the microcirculation by a sufficiently high peripheral blood flow through skin. Also, the viable layers below stratum comeum have high diffusivity. Assume diffusivity for stratum corneum for a low-molecular weight non-electrolyte is 10^-6 m^2/s. How much material enters the skin up to a given time? Simplify for large times and sketch. How much material leaves the stratum corneum into the viable tissue? Simplify for large times and sketch. How much material remains in the stratum corneum? Simplify for large times and sketch.
Transport of Medication Through Skin For a simplified ease of tranpsort through skin, assume total diffusional resistance of skin is entirely due to the stratum corneum (see Figure 5.14). This ignores penetration in sweat duets, etc. This would be sufficiently accurate for relatively rapidly penetrating molecules of small molecular weight. Consider application of a solute to the outer surface of stratum corneum which has a thickness of 1 micron. The partition coefficient relating the membrane surface concentration to the concentration of applied material is 1. The inner surface of stratum corneum is assumed to be maintained at essentially zero concentration since the molecules are removed as soon as they reach the microcirculation by a sufficiently high peripheral blood flow through skin. Also, the viable layers below stratum comeum have high diffusivity. Assume diffusivity for stratum corneum for a low-molecular weight non-electrolyte is 10^-6 m^2/s. How much material enters the skin up to a given time? Simplify for large times and sketch. How much material leaves the stratum corneum into the viable tissue? Simplify for large times and sketch. How much material remains in the stratum corneum? Simplify for large times and sketch.
