Question: Upon binding IL8, the CXCR2 activates four di?erent signaling
pathways: the PI3 Kinase pathway, t…
Upon binding IL8, the CXCR2 activates four di?erent signaling
pathways: the PI3 Kinase pathway, the Phospholipase C (PLC)
pathway, the JAK/STAT pathway, and the MAPK pathway.
1.? Describe the molecular events following activation of each
of these pathways, including formation of secondary messengers, the
target of these messengers, and enzymes involved.
Show transcribed image text Characterized IL-8 signaling pathways. VEGFR EGFR 1L-8 IL-8 CXCR1/2 XGR1/2 CdC42 GTPase RhoGTPase RacGTPase Cytoskeleton P13- Dynamics RasGTP Focal Adhesion Assembly Calcium PKC) mobilization Raf Mek Akt FAK Src → Paxillin →. mTOR Erk1 S6K Actin Nucleation S6 PKC p38 Ak Protein Translation i.-' ERK HIF-1 Angiogenesis Cell survival Cell proliferation Cell proliferation Cell proliferation Cell proliferation Gene NF-KB AP-1 AR STAT3 β-catenin Cell survival Angiogenesis Cell survival Cls Cell metabolism Invasion Cell survivalCell survival Expression survival Cell survival Expression Angiogenesis CCR Molecular Pathways
Characterized IL-8 signaling pathways. VEGFR EGFR 1L-8 IL-8 CXCR1/2 XGR1/2 CdC42 GTPase RhoGTPase RacGTPase Cytoskeleton P13- Dynamics RasGTP Focal Adhesion Assembly Calcium PKC) mobilization Raf Mek Akt FAK Src → Paxillin →. mTOR Erk1 S6K Actin Nucleation S6 PKC p38 Ak Protein Translation i.-' ERK HIF-1 Angiogenesis Cell survival Cell proliferation Cell proliferation Cell proliferation Cell proliferation Gene NF-KB AP-1 AR STAT3 β-catenin Cell survival Angiogenesis Cell survival Cls Cell metabolism Invasion Cell survivalCell survival Expression survival Cell survival Expression Angiogenesis CCR Molecular Pathways
