Question: VERAPAMIL Verapamil Is Used To Treat High Blood Pressure And To Control Angina (chest Pain). Verapamil Undergoes O-demethylation, N-dealkylation, And N-demethylation To A Number Of Different Metabolites Via The Cytochrome P450 Enzyme System. The Following Table Reports Typical Pharmacokinetic Data For The Drug Verapamil BIOAVAILABILITY (ORALSURINARY …

VERAPAMIL Verapamil is used to treat high blood pressure and to control angina (chest pain). Verapamil undergoes O-demethylation, N-dealkylation, and N-demethylation to a number of different metabolites via the cytochrome P450 enzyme system. The following table reports typical pharmacokinetic data for the drug Verapamil BIOAVAILABILITY (ORALSURINARY BOUND IN PLASMAS CLEARANCE m/min VOL DIST. UN HALF-LIFE [hour] EXCRETIONS 22 +8 1902 156 5.0:21 7LD 11.04 1.5 FLD LD ILD 2 LD 1. Is Verapamil a low, medium or high extraction ratio drug? Why? Verapamil is high extraction ratio drug. The drug with a high execration ratio will have their total hepatiqclearance highly dependent on hepatic blood flow, and in low flow states their metabolism will suffer. Ilso, Verapamil is highly protein bound and downstrictixelx cleared by their liver. 2. Predict the changes in clearance, half-life, and volume of distribution in patients with Liver Disease (LD). Note that one of the effects of LD is to slow blood flow through the liver as well as to lower metabolism efficiency. Clearance Vol. Distr Half-live a. Calculate exposure (AUC mg/L/bc) following a 100 mg oral dose of verapamil hydrochloride (MW 491 D to a 58-year-old female (62 kg) patient b. What IV-bolus dose should you administer to obtain the same exposure? C What is the plasma concentration in ug/1. 4 hours from the administration of a 100 mg tablet verapamil-hydrochloride? (Assume 1st order absorption, ka = 2 hrs 1 and the same female patient, 62kg) d. How many microgram of drug are in the body of this patient at t=4 hours?